Modeling Ion Sensitive Field Effect Transistors for Biosensor Applications

During recent decades increasing interest has been shown in the development of biosensors based on ion sensitive field effect transistors (ISFETs). Many ISFET– based pH sensors have been already commercialized and attempts have also been made to commercialize ISFETbased biosensors for applications in the fields of medical, environmental, food safety, military and biotechnology areas. The growing interest for development of these sensors can be explained by the fact that they are manufactured by means of semiconductor techniques which have innovative potential and therefore, may result in the appearance of new biosensor technologies. The basic theoretical principles of ISFET usage in bio analytical practice, the operation principle of ISFET, its modeling and a brief introduction of ISFET technology are considered in this review.